Explore natural selection by controlling the environment and causing mutations in bunnies.
An introduction to reading and analyzing pedigrees.
In this activity students analyze a familys pedigrees to make a claim based on evidence about mode of inheritance of a lactose intolerance trait, determine the most likely inheritance pattern of a trait, and analyze variations in DNA to make a claim about which variants are associated with specific traits. This activity serves as a supplement to the film Got Lactose? The Co-evolution of Genes and Culture (http://www.hhmi.org/biointeractive/making-fittest-got-lactase-co-evolution-genes-and-culture). The film shows a scientist as he tracks down the genetic changes associated with the ability to digest lactose as adults. A detailed teachers guide that includes curriculum connections, teaching tips, time requirements, answer key and a student guide can be downloaded at http://www.hhmi.org/biointeractive/pedigrees-and-inheritance-lactose-intolerance. Six supporting resource and two click and learn activities are also found on the link.
How homologous chromosomes separate into two sets. Prophase I, metaphase I, anaphase I, and telophase I.
How sister chromatids separate to form gametes. Prophase II, metaphase II, anaphase II, telophase II.
Introduction to PCR (polymerase chain reaction).
Watch how NJ high school students apply basic principles of molecular biology to solve real research problems, and publish their own genome research at GenBank, the international genomic sequence database.
In this video segment adapted from NOVA scienceNOW, learn about RNAi's potential to treat a wide range of genetic and infectious diseases.
Students create and decode DNA for mans best friend to observe how variations in DNA lead to the inheritance of different traits. Strips of paper that represent DNA are randomly selected and used to assemble the dog's DNA. Students read the DNA and create a drawing of their pet, and compare it with others in the class to check for similarities and differences.
This video segment from Kentucky Life describes how scientists control pollination of one of the few remaining American chestnut trees to develop blight resistant trees.
The discovery of restriction enzymes and their applications in DNA analysis has proven to be essential for biologists and chemists. This lesson focuses on restriction enzymes and their applications to DNA analysis and DNA fingerprinting. Use this lesson and its associated activity in conjunction with biology lessons on DNA analysis and DNA replication.
By this point in the unit, students have learned all the necessary information and conceptualized a design for how an optical biosensor could be used to detect a target strand of DNA associated with a cancer-causing gene as their solution to the unit's challenge question. Now student groups act as engineers again, using a poster format to communicate and prove the validity of the design. Successful posters include a description of refraction, explanations of refraction in a thin film, and the factors that can alter the interference pattern of a thin film. The posters culminate with an explanation of what is expected to be seen in a biosensing device of this type if it were coupled to a target molecule, proven with a specific example and illustrated with drawings and diagrams throughout. All the poster elements combine to prove the accuracy and viability of this method of gene detection. Together with its associated lesson, this activity functions as part of the summative assessment for this unit.
Explore stretching just a single strand of DNA using optical tweezers or fluid flow. Experiment with the forces involved and measure the relationship between the stretched DNA length and the force required to keep it stretched. Is DNA more like a rope or like a spring?
Explore stretching just a single strand of DNA using optical tweezers or fluid flow. Experiment with the forces involved and measure the relationship between the stretched DNA length and the force required to keep it stretched. Is DNA more like a rope or like a spring?
Students observe natural selection in action and investigate the underlying mechanism, including random mutation and differential fitness based on environmental characteristics. They do this through use of the free AVIDA-ED digital evolution software application.
Students engineer and evolve digital organisms with the challenge to produce organisms with the highest fitness values in a particular environment. They do this through use of the free Avida-ED digital evolution software application. The resulting organisms compete against each other in the same environment and students learn the benefits of applying the principles of natural selection to solve engineering design problems.
How is it that all cells in our body have the same genes, yet cells in different tissues express different genes? A basic notion in biology that most high school students fail to conceptualize is the fact that all cells in the animal or human body contain the same DNA, yet different cells in different tissues express, on the one hand, a set of common genes, and on the other, express another set of genes that vary depending on the type of tissue and the stage of development. In this video lesson, the student will be reminded that genes in a cell/tissue are expressed when certain conditions in the nucleus are met. Interestingly, the system utilized by the cell to ensure tissue specific gene expression is rather simple. Among other factors - all discussed fully in the lesson - the cells make use of a tiny scaffold known as the “Nuclear Matrix or Nucleo-Skeleton”. This video lesson spans 20 minutes and provides 5 exercises for students to work out in groups and in consultation with their classroom teacher. The entire duration of the video demonstration and exercises should take about 45-50 minutes, or equivalent to one classroom session. There are no supplies needed for students’ participation in the provided exercises. They will only need their notebooks and pens. However, the teacher may wish to emulate the demonstrations used in the video lesson by the presenter and in this case simple material can be used as those used in the video. These include play dough, pencils, rubber bands (to construct the nuclear matrix model), a tennis ball and 2-3 Meters worth of shoe laces. The students should be aware of basic information about DNA folding in the nucleus, DNA replication, gene transcription, translation and protein synthesis.
This graphic from Biology by Kenneth R. Miller and Joseph Levine suggests how some recent hominid fossil finds might fit into the overall picture of hominid evolution. As more fossils are found and further analysis advances our understanding of human evolution, this picture will almost certainly be revised.
it would be ideal if students already have learned that DNA is the genetic material, and that DNA is made up of As, Ts, Gs, and Cs. It also would help if students already know that each human has two versions of every piece of DNA in their genome, one from mom and one from dad. The lesson will take about one class period, with roughly 30 minutes of footage and 30 minutes of activities.
In a class discussion format, the teacher presents background information about basic human genetics. The number of chromosomes in both body cells and egg and sperm cells is covered, as well as the concept of dominant and recessive alleles. Students determine whether or not they possess the dominant allele for the tongue-rolling gene as an example.